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KMID : 0545120080180020377
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Journal of Microbiology and Biotechnology
2008 Volume.18 No. 2 p.377 ~ p.382
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Interleukin-2 Promotes Angiogenesis by Activation of Akt and Increase of ROS
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Bae Jin-Hee
Park Deok-Bum
Lee Yun-Sil
Jeoung Doo-Il
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Abstract
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Interleukin-2 plays a significant role in T cell proliferation. Here, we report the role of IL-2 in angiogenesis. IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs). IL-2 increased angiogenesis in an animal model and tube formation in HUVECs. The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt. This is the first report that IL-2 promotes angiogenesis.
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KEYWORD
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Angiogenesis, interleukin-2, reactive oxygen species, serine/threonine kinase Akt
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